Sex-specific modulation of spinal nociception by α(2)-adrenoceptors: differential regulation by estrogen and testosterone

Por Thompson, Analisa D., Angelotti, Timothy, Nag, Subodh, Mokha, Sukhbir S.
Publicado em 2008

Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia

Por Lawson, Kera P., Nag, Subodh, Thompson, Analisa D., Mokha, Sukhbir S.
Publicado em 2010

Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson's Disease

Por Xiang, Zixiu, Thompson, Analisa D., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Publicado em 2012

A Rodent Model of Traumatic Stress Induces Lasting Sleep and Quantitative Electroencephalographic Disturbances

Por Nedelcovych, Michael T., Gould, Robert W., Zhan, Xiaoyan, Bubser, Michael, Gong, Xuewen, Grannan, Michael, Thompson, Analisa T., Ivarsson, Magnus, Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Publicado no ACS Chem Neurosci (2015)

Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric...

Por Iderberg, Hanna, Maslava, Natallia, Thompson, Analisa D., Bubser, Michael, Niswender, Colleen M., Hopkins, Corey R., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K., Cenci, M. Angela
Publicado no Neuropharmacology (2015)

Centrally Active Allosteric Potentiators of the M(4) Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

Por Brady, Ashley E., Jones, Carrie K., Bridges, Thomas M., Kennedy, J. Phillip, Thompson, Analisa D., Heiman, Justin U., Breininger, Micah L., Gentry, Patrick R., Yin, Huiyong, Jadhav, Satyawan B., Shirey, Jana K., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2008

Discovery of (S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Pep...

Por Morris, Lindsey C., Nance, Kellie D., Gentry, Patrick R., Days, Emily L., Weaver, C. David, Niswender, Colleen M., Thompson, Analisa D., Jones, Carrie K., Locuson, Chuck W., Morrison, Ryan D., Daniels, J. Scott, Niswender, Kevin D., Lindsley, Craig W.
Publicado no J Med Chem (2014)

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

Por Gogliotti, Rocco D., Engers, Darren W., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Gentry, Patrick R., Blobaum, Anna L., Morrison, Ryan D., Daniels, J. Scott, Thompson, Analisa D., Jones, Carrie K., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Publicado no Bioorg Med Chem Lett (2016)

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

Por Nickols, Hilary Highfield, Yuh, Joannes P., Gregory, Karen J., Morrison, Ryan D., Bates, Brittney S., Stauffer, Shaun R., Emmitte, Kyle A., Bubser, Michael, Peng, Weimin, Nedelcovych, Michael T., Thompson, Analisa, Lv, Xiaohui, Xiang, Zixiu, Daniels, J. Scott, Niswender, Colleen M., Lindsley, Craig W., Jones, Carrie K., Conn, P. Jeffrey
Publicado no J Pharmacol Exp Ther (2016)

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Por Engers, Julie L., Rodriguez, Alice L., Konkol, Leah C., Morrison, Ryan D., Thompson, Analisa D., Byers, Frank W., Blobaum, Anna L., Chang, Sichen, Venable, Daryl F., Loch, Matthew T., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no J Med Chem (2015)

The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Ro...

Por Jones, Carrie K., Bubser, Michael, Thompson, Analisa D., Dickerson, Jonathan W., Turle-Lorenzo, Nathalie, Amalric, Marianne, Blobaum, Anna L., Bridges, Thomas M., Morrison, Ryan D., Jadhav, Satyawan, Engers, Darren W., Italiano, Kimberly, Bode, Jacob, Daniels, J. Scott, Lindsley, Craig W., Hopkins, Corey R., Conn, P. Jeffrey, Niswender, Colleen M.
Publicado em 2012

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4

Por Niswender, Colleen M., Johnson, Kari A., Weaver, C. David, Jones, Carrie K., Xiang, Zixiu, Luo, Qingwei, Rodriguez, Alice L., Marlo, Joy E., de Paulis, Tomas, Thompson, Analisa D., Days, Emily L., Nalywajko, Tasha, Aust, Cheryl A., Williams, Michael Baxter, Ayala, Jennifer E., Williams, Richard, Lindsley, Craig W., Conn, P. Jeffrey
Publicado em 2008

Discovery, Synthesis, SAR Development of a Series of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulato...

Por Jones, Carrie K., Engers, Darren W., Thompson, Analisa D., Field, Julie R., Blobaum, Anna L., Lindsley, Stacey R., Zhou, Ya, Gogliotti, Rocco D., Jadhav, Satyawan, Zamorano, Rocio, Bogenpohl, Jim, Smith, Yoland, Morrison, Ryan, Daniels, J. Scott, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.
Publicado em 2011

Antipsychotic Drug-Like Effects of the Selective M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Por Byun, Nellie E, Grannan, Michael, Bubser, Michael, Barry, Robert L, Thompson, Analisa, Rosanelli, John, Gowrishankar, Raajaram, Kelm, Nathaniel D, Damon, Stephen, Bridges, Thomas M, Melancon, Bruce J, Tarr, James C, Brogan, John T, Avison, Malcolm J, Deutch, Ariel Y, Wess, Jürgen, Wood, Michael R, Lindsley, Craig W, Gore, John C, Conn, P Jeffrey, Jones, Carrie K
Publicado em 2014

Partial mGlu(5) Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects

Por Gould, Robert W, Amato, Russell J, Bubser, Michael, Joffe, Max E, Nedelcovych, Michael T, Thompson, Analisa D, Nickols, Hilary H, Yuh, Johannes P, Zhan, Xiaoyan, Felts, Andrew S, Rodriguez, Alice L, Morrison, Ryan D, Byers, Frank W, Rook, Jerri M, Daniels, John S, Niswender, Colleen M, Conn, P Jeffrey, Emmitte, Kyle A, Lindsley, Craig W, Jones, Carrie K
Publicado no Neuropsychopharmacology (2016)

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Dise...

Por Xiang, Zixiu, Thompson, Analisa D., Brogan, John T., Schulte, Michael L., Melancon, Bruce J., Mi, Debbie, Lewis, L. Michelle, Zou, Bende, Yang, Liya, Morrison, Ryan, Santomango, Tammy, Byers, Frank, Brewer, Katrina, Aldrich, Jonathan S., Yu, Haibo, Dawson, Eric S., Li, Min, McManus, Owen, Jones, Carrie K., Daniels, J. Scott, Hopkins, Corey R., Xie, Ximin Simon, Conn, P. Jeffrey, Weaver, C. David, Lindsley, Craig W.
Publicado em 2011

Biased mGlu(5) positive allosteric modulators provide in vivo efficacy without potentiating mGlu(5) modulation of NMDAR currents

Por Rook, Jerri M., Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W., Bridges, Thomas M., Johnson, Kari A., Foster, Daniel J., Gregory, Karen J., Vinson, Paige N., Thompson, Analisa D., Byun, Nellie, Collier, Rebekah L., Bubser, Michael, Nedelcovych, Michael T., Gould, Robert W., Stauffer, Shaun R., Daniels, J. Scott, Niswender, Colleen M., Lavreysen, Hilde, Mackie, Claire, Conde-Ceide, Susana, Alcazar, Jesus, Bartolomé-Nebreda, José M., Macdonald, Gregor J., Steckler, Thomas, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Publicado no Neuron (2015)