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Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson's Disease

Antagonists of the muscarinic acetylcholine receptors (mAChRs) were among the first treatments for Parkinson's disease. However, the clinical utility of mAChR antagonists is limited by adverse effects associated with the blockade of multiple mAChR subtypes. Understanding the roles of specific m...

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Detalhes bibliográficos
Main Authors: Xiang, Zixiu, Thompson, Analisa D., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286317/
https://ncbi.nlm.nih.gov/pubmed/22135383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.187856
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