Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications

Por Yin, Shen, Niswender, Colleen M.
Publicado em 2014

mGluR7's lucky number

Por Conn, P. Jeffrey, Niswender, Colleen M.
Publicado em 2006

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

Por Niswender, Colleen M., Conn, P. Jeffrey
Publicado em 2010

Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors

Por Klein, Michael T., Vinson, Paige N., Niswender, Colleen M.
Publicado no Prog Mol Biol Transl Sci (2013)

mGluR4-positive allosteric modulation as potential treatment for Parkinson’s disease

Por Hopkins, Corey R, Lindsley, Craig W, Niswender, Colleen M
Publicado em 2009

Glutamate receptors as therapeutic targets for Parkinson’s disease

Por Johnson, Kari A., Conn, P. Jeffrey, Niswender, Colleen M.
Publicado em 2009

Functional selectivity induced by mGlu(4) receptor positive allosteric modulation and concomitant activation of G(q) coupled receptors

Por Yin, Shen, Zamorano, Rocio, Conn, P. Jeffrey, Niswender, Colleen M.
Publicado em 2012

Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata

Por Johnson, Kari A., Niswender, Colleen M., Conn, P. Jeffrey, Xiang, Zixiu
Publicado em 2011

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

Por Conn, P. Jeffrey, Lindsley, Craig W., Meiler, Jens, Niswender, Colleen M.
Publicado em 2014

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

Por Willis, Brandon S., Niswender, Colleen M., Su, Thomas, Amieux, Paul S., McKnight, G. Stanley
Publicado em 2011

Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated

Por Ayala, Jennifer E., Niswender, Colleen M., Luo, Qingwei, Banko, Jessica L., Conn, P. Jeffrey
Publicado em 2007

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

Por Williams, Richard, Niswender, Colleen M., Luo, Qingwei, Le, Uyen, Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2008

The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies

Por Senter, Rebecca K., Ghoshal, Ayan, Walker, Adam G., Xiang, Zixiu, Niswender, Colleen M., Conn, P. Jeffrey
Publicado no Curr Neuropharmacol (2016)

RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity

Por Berg, Kelly A, Cropper, Jodie D, Niswender, Colleen M, Sanders-Bush, Elaine, Emeson, Ronald B, Clarke, William P
Publicado em 2001

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

Por Williams, Richard, Zhou, Ya, Niswender, Colleen M., Luo, Qingwei, Conn, P. Jeffrey, Lindsley, Craig W., Hopkins, Corey R.
Publicado em 2010

Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 1. SAR of modifications to the central aryl core

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2015)

Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs

Por Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Genetic Reduction or Negative Modulation of mGlu(7) Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome

Por Fisher, Nicole M., Gogliotti, Rocco G., Vermudez, Sheryl Anne D., Stansley, Branden J., Conn, P. Jeffrey, Niswender, Colleen M.
Publicado no ACS Chem Neurosci (2017)

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

Por Hammond, Alexis S., Rodriguez, Alice L., Townsend, Steven D., Niswender, Colleen M., Gregory, Karen J., Lindsley, Craig W., Conn, P. Jeffrey
Publicado em 2010

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modula...

Por Niswender, Colleen M., Lebois, Evan P., Luo, Qingwei, Kim, Kwangho, Muchalski, Hubert, Yin, Huiyong, Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2008