A carregar...
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead
This Letter describes the synthesis and SAR of two mGluR4 positive allosteric modulator leads, 6 and 7. VU001171 (6) represents the most potent (EC(50) = 650 nM), efficacious (141% Glu Max) and largest fold shift (36-fold) of any mGluR4 PAM reported to date. However, this work highlights the challen...
Na minha lista:
| Main Authors: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787871/ https://ncbi.nlm.nih.gov/pubmed/19097893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.11.104 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|