Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

[Image: see text] This paper describes a detailed structure−activity relationship (SAR) analysis of the metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator, (−)-N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide (PHCCC). We have now developed compounds with improved po...

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Bibliographic Details
Main Authors: Williams, Richard, Zhou, Ya, Niswender, Colleen M., Luo, Qingwei, Conn, P. Jeffrey, Lindsley, Craig W., Hopkins, Corey R.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2010
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889702/
https://ncbi.nlm.nih.gov/pubmed/20582156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn9000318
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