Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

This Letter describes the synthesis and SAR, developed through an iterative analogue library approach, of an mGluR4 positive allosteric modulator lead based on a pyrazolo[3,4-d]pyrimidine scaffold. Despite tremendous therapeutic potential, Compound 7, VU0080421, and related congeners represent only...

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Détails bibliographiques
Auteurs principaux: Niswender, Colleen M., Lebois, Evan P., Luo, Qingwei, Kim, Kwangho, Muchalski, Hubert, Yin, Huiyong, Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182458/
https://ncbi.nlm.nih.gov/pubmed/18793851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.08.087
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