Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor

[Image: see text] Novel oxazolobenzimidazoles are described as potent and selective positive allosteric modulators of the metabotropic glutamate receptor 2. The discovery of this class and optimization of its physical and pharmacokinetic properties led to the identification of potent and orally bioa...

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Bibliografiske detaljer
Main Authors: Garbaccio, Robert M., Brnardic, Edward J., Fraley, Mark E., Hartman, George D., Hutson, Pete H., O'Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillgrove, Kerry L., Small, James H., Tang, Cuyue, Kuo, Yuhsin, Jacobson, Marlene A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2010
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007895/
https://ncbi.nlm.nih.gov/pubmed/24900224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100115a
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