ADME of Biologics—What Have We Learned from Small Molecules?

Por Prueksaritanont, Thomayant, Tang, Cuyue
Publicado em 2012

Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations

Por Prueksaritanont, Thomayant, Ma, Bennett, Tang, Cuyue, Meng, Yuan, Assang, Carol, Lu, Ping, Reider, Paul J, Lin, Jiunn H, Baillie, Thomas A
Publicado em 1999

Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor

Por Garbaccio, Robert M., Brnardic, Edward J., Fraley, Mark E., Hartman, George D., Hutson, Pete H., O'Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillgrove, Kerry L., Small, James H., Tang, Cuyue, Kuo, Yuhsin, Jacobson, Marlene A.
Publicado em 2010

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

Por Blain, Jean-François, Bursavich, Matthew G., Freeman, Emily A., Hrdlicka, Lori A., Hodgdon, Hilliary E., Chen, Ting, Costa, Don E., Harrison, Bryce A., Kapadnis, Sudarshan, Murphy, Deirdre A., Nolan, Scott, Tu, Zhiming, Tang, Cuyue, Burnett, Duane A., Patzke, Holger, Koenig, Gerhard
Publicado no Alzheimers Res Ther (2016)

Antagonism of T-type calcium channels inhibits high-fat diet–induced weight gain in mice

Por Uebele, Victor N., Gotter, Anthony L., Nuss, Cindy E., Kraus, Richard L., Doran, Scott M., Garson, Susan L., Reiss, Duane R., Li, Yuxing, Barrow, James C., Reger, Thomas S., Yang, Zhi-Qiang, Ballard, Jeanine E., Tang, Cuyue, Metzger, Joseph M., Wang, Sheng-Ping, Koblan, Kenneth S., Renger, John J.
Publicado em 2009

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI

Por Pero, Joseph E., Rossi, Michael A., Kelly, Michael J., Lehman, Hannah D. G. F., Layton, Mark E., Garbaccio, Robert M., O’Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Joyce, Leo A., Sherer, Edward C., Jacobson, Marlene A.
Publicado no ACS Med Chem Lett (2016)

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists

Por Barrow, James C., Rittle, Kenneth E., Reger, Thomas S., Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B., Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Kraus, Richard L., Li, Yuxing, Marino, Michael J., Kuzmick Graufelds, Valerie, Uebele, Victor N., Renger, John J.
Publicado em 2010

Short-Acting T-Type Calcium Channel Antagonists Significantly Modify Sleep Architecture in Rodents

Por Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Reger, Thomas S., Cube, Rowena, Mattern, Christa, Coleman, Paul J., Small, Jim, Hartman, George D., Ballard, Jeanine, Tang, Cuyue, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott, Fox, Steve V., Garson, Susan L., Li, Yuxing, Kraus, Richard L., Uebele, Victor N., Taylor, Adekemi B., Zeng, Wei, Fang, Wei, Chavez-Eng, Cynthia, Troyer, Matthew D., Luk, Julie Ann, Laethem, Tine, Cook, William O., Renger, John J., Barrow, James C.
Publicado em 2010