Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

BACKGROUND: Familial Alzheimer’s disease (FAD) is caused by mutations in the amyloid precursor protein (APP) or presenilin (PS). Most PS mutations, which account for the majority of FAD cases, lead to an increased ratio of longer to shorter forms of the amyloid beta (Aβ) peptide. The therapeutic rat...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Blain, Jean-François, Bursavich, Matthew G., Freeman, Emily A., Hrdlicka, Lori A., Hodgdon, Hilliary E., Chen, Ting, Costa, Don E., Harrison, Bryce A., Kapadnis, Sudarshan, Murphy, Deirdre A., Nolan, Scott, Tu, Zhiming, Tang, Cuyue, Burnett, Duane A., Patzke, Holger, Koenig, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004293/
https://ncbi.nlm.nih.gov/pubmed/27572246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0199-5
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