Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

BACKGROUND: Familial Alzheimer’s disease (FAD) is caused by mutations in the amyloid precursor protein (APP) or presenilin (PS). Most PS mutations, which account for the majority of FAD cases, lead to an increased ratio of longer to shorter forms of the amyloid beta (Aβ) peptide. The therapeutic rat...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Alzheimers Res Ther
Egile Nagusiak: Blain, Jean-François, Bursavich, Matthew G., Freeman, Emily A., Hrdlicka, Lori A., Hodgdon, Hilliary E., Chen, Ting, Costa, Don E., Harrison, Bryce A., Kapadnis, Sudarshan, Murphy, Deirdre A., Nolan, Scott, Tu, Zhiming, Tang, Cuyue, Burnett, Duane A., Patzke, Holger, Koenig, Gerhard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2016
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004293/
https://ncbi.nlm.nih.gov/pubmed/27572246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0199-5
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