Synthesis and Evaluation of a Series of Heterobiaryl Amides that are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)

We report the synthesis and evaluation of a series of heterobiaryl amides as positive allosteric modulators of mGluR4. Compounds 9b and 9c showed submicromolar potency at both human and rat mGluR4. In addition, both 9b and 9c were shown to be centrally penetrant in rats using nontoxic vehicles, a ma...

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Detalhes bibliográficos
Main Authors: Engers, Darren W., Niswender, Colleen M., Weaver, C. David, Jadhav, Satyawan, Menon, Usha N., Zamorano, Rocio, Conn, P. Jeffrey, Lindsley, Craig W., Hopkins, Corey R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765192/
https://ncbi.nlm.nih.gov/pubmed/19469556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9005065
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