Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

[Image: see text] We previously discovered a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu(5)) termed 4 N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) that elicits receptor activation through a novel allos...

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Detaylı Bibliyografya
Asıl Yazarlar: Hammond, Alexis S., Rodriguez, Alice L., Townsend, Steven D., Niswender, Colleen M., Gregory, Karen J., Lindsley, Craig W., Conn, P. Jeffrey
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2010
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957851/
https://ncbi.nlm.nih.gov/pubmed/20981342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100051m
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