Discovery of Molecular Switches within the ADX-47273 mGlu(5) PAM scaffold that modulate modes of pharmacology to afford potent mGlu(5) NAMs, PAMs and partial antagonists

Por Lamb, Jeffrey P., Engers, Darren W., Niswender, Colleen M., Rodriguez, Alice L., Venable, Daryl F., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2010

A Novel Class of Succinimide-Derived Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Provides Insight into a Disconnect in Activity between the Rat and...

Por Cho, Hyekyung P., Engers, Darren W., Venable, Daryl F., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Emmitte, Kyle A., Rodriguez, Alice L.
Publicado em 2014

Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)

Por Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu(5): Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction

Por Amato, Russell J., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Jones, Carrie K., Emmitte, Kyle A.
Publicado em 2013

N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu(1): Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

Por Lovell, Kimberly M., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Cho, Hyekyung P., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

N-Alkylpyrido[1′,2′:1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu(1/5) with CNS exposure in rodents

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no Bioorg Med Chem Lett (2016)

Chemical Modulation of Mutant mGlu(1) Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

Por Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Brogan, John T., Hopkins, Corey R., Niswender, Colleen M., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Bubser, Michael, Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2014

Discovery of VU0409106: A negative allosteric modulator of mGlu(5) with activity in a mouse model of anxiety

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2013

Discovery of VU0431316: A negative allosteric modulator of mGlu(5) with activity in a mouse model of anxiety

Por Bates, Brittney S., Rodriguez, Alice L., Felts, Andrew S., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Lawson, Kera P., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado em 2014

Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Por Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Bollinger, Katrina A., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Gray, Analisa Thompson, Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no Bioorg Med Chem Lett (2017)

Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

Por Felts, Andrew S., Rodriguez, Alice L., Smith, Katrina A., Engers, Julie L., Morrison, Ryan D., Byers, Frank W., Blobaum, Anna L., Locuson, Charles W., Chang, Sichen, Venable, Daryl F., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no J Med Chem (2015)

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Por Engers, Julie L., Rodriguez, Alice L., Konkol, Leah C., Morrison, Ryan D., Thompson, Analisa D., Byers, Frank W., Blobaum, Anna L., Chang, Sichen, Venable, Daryl F., Loch, Matthew T., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no J Med Chem (2015)

Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Sel...

Por Felts, Andrew S., Rodriguez, Alice L., Blobaum, Anna L., Morrison, Ryan D., Bates, Brittney S., Thompson Gray, Analisa, Rook, Jerri M., Tantawy, Mohammed N., Byers, Frank W., Chang, Sichen, Venable, Daryl F., Luscombe, Vincent B., Tamagnan, Gilles D., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Publicado no J Med Chem (2017)

The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5

Por Morrison, Ryan D., Blobaum, Anna L., Byers, Frank W., Santomango, Tammy S., Bridges, Thomas M., Stec, Donald, Brewer, Katrina A., Sanchez-Ponce, Raymundo, Corlew, Melany M., Rush, Roger, Felts, Andrew S., Manka, Jason, Bates, Brittney S., Venable, Daryl F., Rodriguez, Alice L., Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A., Daniels, J. Scott
Publicado em 2012