Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Based on a hypothesis that an intramolecular hydrogen bond was present in our lead series of picolinamide mGlu(5) NAMs, we reasoned that an inactive nicotinamide series could be modified through introduction of a fused heterocyclic core to generate potent mGlu(5) NAMs. In this Letter, we describe th...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Bollinger, Katrina A., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Gray, Analisa Thompson, Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716465/
https://ncbi.nlm.nih.gov/pubmed/28958625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.09.042
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