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Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
Based on a hypothesis that an intramolecular hydrogen bond was present in our lead series of picolinamide mGlu(5) NAMs, we reasoned that an inactive nicotinamide series could be modified through introduction of a fused heterocyclic core to generate potent mGlu(5) NAMs. In this Letter, we describe th...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Bioorg Med Chem Lett |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716465/ https://ncbi.nlm.nih.gov/pubmed/28958625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.09.042 |
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