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Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

Both orthosteric and allosteric antagonists of the group II metabotropic glutamate receptors (mGlus) have been used to establish a link between mGlu(2/3) inhibition and a variety of CNS diseases and disorders. Though these tools typically have good selectivity for mGlu(2/3) versus the remaining six...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Felts, Andrew S., Rodriguez, Alice L., Smith, Katrina A., Engers, Julie L., Morrison, Ryan D., Byers, Frank W., Blobaum, Anna L., Locuson, Charles W., Chang, Sichen, Venable, Daryl F., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817271/
https://ncbi.nlm.nih.gov/pubmed/26524606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01371
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