Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Based on previous work that established fused heterocycles as viable alternatives for the picolinamide core of our lead series of mGlu(5) negative allosteric modulators (NAMs), we designed a novel series of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide mGlu(5) NAMs. These new quinoline derivatives...

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Publicado no:Bioorg Med Chem Lett
Main Authors: Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142812/
https://ncbi.nlm.nih.gov/pubmed/29705142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.04.053
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