N-Alkylpyrido[1′,2′:1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu(1/5) with CNS exposure in rodents

Selective negative allosteric modulators (NAMs) of each of the group I metabotropic glutamate receptors (mGlu(1) and mGlu(5)) have been well characterized in the literature and offer potential as therapeutics in several disorders of the central nervous system (CNS). Still, compounds that are potent...

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Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824313/
https://ncbi.nlm.nih.gov/pubmed/26988308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.026
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