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N-Alkylpyrido[1′,2′:1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu(1/5) with CNS exposure in rodents
Selective negative allosteric modulators (NAMs) of each of the group I metabotropic glutamate receptors (mGlu(1) and mGlu(5)) have been well characterized in the literature and offer potential as therapeutics in several disorders of the central nervous system (CNS). Still, compounds that are potent...
Shranjeno v:
| izdano v: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824313/ https://ncbi.nlm.nih.gov/pubmed/26988308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.026 |
| Oznake: |
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