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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)

Development of SAR in an octahydropyrrolo[3,4-c]pyrrole series of negative allosteric modulators of mGlu(1) using a functional cell-based assay is described in this Letter. The octahydropyrrolo[3,4-c]pyrrole scaffold was chosen as an isosteric replacement for the piperazine ring found in the initial...

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Dettagli Bibliografici
Autori principali: Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901432/
https://ncbi.nlm.nih.gov/pubmed/23932792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.07.029
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