Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu(1)

Development of SAR in an octahydropyrrolo[3,4-c]pyrrole series of negative allosteric modulators of mGlu(1) using a functional cell-based assay is described in this Letter. The octahydropyrrolo[3,4-c]pyrrole scaffold was chosen as an isosteric replacement for the piperazine ring found in the initial...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901432/
https://ncbi.nlm.nih.gov/pubmed/23932792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.07.029
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