N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu(1): Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

Development of SAR in an N-acyl-N′-arylpiperazine series of negative allosteric modulators of mGlu(1) using a functional cell-based assay is described in this Letter. Characterization of selected compounds in protein binding assays was used to aid in selecting VU0469650 for further profiling in anci...

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Détails bibliographiques
Auteurs principaux: Lovell, Kimberly M., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Cho, Hyekyung P., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875306/
https://ncbi.nlm.nih.gov/pubmed/23727046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.020
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