N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu(1): Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

Development of SAR in an N-acyl-N′-arylpiperazine series of negative allosteric modulators of mGlu(1) using a functional cell-based assay is described in this Letter. Characterization of selected compounds in protein binding assays was used to aid in selecting VU0469650 for further profiling in anci...

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Xehetasun bibliografikoak
Egile Nagusiak: Lovell, Kimberly M., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Cho, Hyekyung P., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875306/
https://ncbi.nlm.nih.gov/pubmed/23727046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.020
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