Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu(5): Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction

[Image: see text] Cocaine is a powerful and highly addictive stimulant that disrupts the normal reward circuitry in the central nervous system (CNS), producing euphoric effects. Cocaine use can lead to acute and life threatening emergencies, and abuse is associated with increased risk for contractin...

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Detalhes bibliográficos
Main Authors: Amato, Russell J., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Jones, Carrie K., Emmitte, Kyle A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750677/
https://ncbi.nlm.nih.gov/pubmed/23682684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400070k
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