Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu(5): Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction

[Image: see text] Cocaine is a powerful and highly addictive stimulant that disrupts the normal reward circuitry in the central nervous system (CNS), producing euphoric effects. Cocaine use can lead to acute and life threatening emergencies, and abuse is associated with increased risk for contractin...

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Main Authors: Amato, Russell J., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Jones, Carrie K., Emmitte, Kyle A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2013
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750677/
https://ncbi.nlm.nih.gov/pubmed/23682684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400070k
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