Partial mGlu(5) Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects

Cocaine abuse remains a public health concern for which pharmacotherapies are largely ineffective. Comorbidities between cocaine abuse, depression, and anxiety support the development of novel treatments targeting multiple symptom clusters. Selective negative allosteric modulators (NAMs) targeting t...

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Publicat a:Neuropsychopharmacology
Autors principals: Gould, Robert W, Amato, Russell J, Bubser, Michael, Joffe, Max E, Nedelcovych, Michael T, Thompson, Analisa D, Nickols, Hilary H, Yuh, Johannes P, Zhan, Xiaoyan, Felts, Andrew S, Rodriguez, Alice L, Morrison, Ryan D, Byers, Frank W, Rook, Jerri M, Daniels, John S, Niswender, Colleen M, Conn, P Jeffrey, Emmitte, Kyle A, Lindsley, Craig W, Jones, Carrie K
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748441/
https://ncbi.nlm.nih.gov/pubmed/26315507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.265
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