Biased mGlu(5) positive allosteric modulators provide in vivo efficacy without potentiating mGlu(5) modulation of NMDAR currents

Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate receptor subtype 5 (mGlu(5)) is a closely associated signaling partner with NMDARs and regulates NMDAR function in forebrain regi...

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Publicado no:Neuron
Main Authors: Rook, Jerri M., Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W., Bridges, Thomas M., Johnson, Kari A., Foster, Daniel J., Gregory, Karen J., Vinson, Paige N., Thompson, Analisa D., Byun, Nellie, Collier, Rebekah L., Bubser, Michael, Nedelcovych, Michael T., Gould, Robert W., Stauffer, Shaun R., Daniels, J. Scott, Niswender, Colleen M., Lavreysen, Hilde, Mackie, Claire, Conde-Ceide, Susana, Alcazar, Jesus, Bartolomé-Nebreda, José M., Macdonald, Gregor J., Steckler, Thomas, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443790/
https://ncbi.nlm.nih.gov/pubmed/25937172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.03.063
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