mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling

[Image: see text] Metabotropic glutamate (mGlu) receptor type 5 (mGlu(5)) positive allosteric modulators (PAMs) enhance hippocampal long-term potentiation (LTP) and have cognition-enhancing effects in animal models. These effects were initially thought to be mediated by potentiation of mGlu(5) modul...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Xiang, Zixiu, Lv, Xiaohui, Maksymetz, James, Stansley, Branden J., Ghoshal, Ayan, Gogliotti, Rocco G., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591772/
https://ncbi.nlm.nih.gov/pubmed/31259318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00017
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