mGlu(5) positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome

Rett syndrome (RS) is a neurodevelopmental disorder that shares many symptomatic and pathological commonalities with idiopathic autism. Alterations in protein synthesis-dependent synaptic plasticity (PSDSP) are a hallmark of a number of syndromic forms of autism; in the present work, we explore the...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Gogliotti, Rocco G., Senter, Rebecca K., Rook, Jerri M., Ghoshal, Ayan, Zamorano, Rocio, Malosh, Chrysa, Stauffer, Shaun R., Bridges, Thomas M., Bartolome, Jose M., Daniels, J. Scott, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062588/
https://ncbi.nlm.nih.gov/pubmed/26936821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw074
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