Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death

Por Ahowesso, Constance, Black, Paul N., Saini, Nipun, Montefusco, David, Chekal, Jessica, Malosh, Chrysa, Lindsley, Craig W., Stauffer, Shaun R., DiRusso, Concetta C.
Publicado no Biochem Pharmacol (2015)

mGlu(5) positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome

Por Gogliotti, Rocco G., Senter, Rebecca K., Rook, Jerri M., Ghoshal, Ayan, Zamorano, Rocio, Malosh, Chrysa, Stauffer, Shaun R., Bridges, Thomas M., Bartolome, Jose M., Daniels, J. Scott, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M.
Publicado no Hum Mol Genet (2016)

Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site

Por Gregory, Karen J., Nguyen, Elizabeth D., Malosh, Chrysa, Mendenhall, Jeffrey L., Zic, Jessica Z., Bates, Brittney S., Noetzel, Meredith J., Squire, Emma F., Turner, Eric M., Rook, Jerri M., Emmitte, Kyle A., Stauffer, Shaun R., Lindsley, Craig W., Meiler, Jens, Conn, P. Jeffrey
Publicado em 2014

Further optimization of the mGlu(5) PAM clinical candidate VU0409551/JNJ-46778212: progress and challenges towards a back-up compound

Por Zhou, Ya, Malosh, Chrysa, Conde-Ceide, Susana, Martínez-Viturro, Carlos Manuel, Alcázar, Jesus, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2015)

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators

Por Malosh, Chrysa, Turlington, Mark, Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Piedrafita, María, Sánchez-Casado, M. Rosa, Macdonald, Gregor J., Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Publicado no Bioorg Med Chem Lett (2015)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))

Por Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T., Noetzel, Meredith J., Vinson, Paige N., Jadhav, Satyawan, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Martín-Martín, M. Luz, Tong, Han Min, López, Silvia, MacDonald, Gregor J., Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Publicado em 2014