Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu(5))

Por Martín-Martín, María Luz, Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Alonso de Diego, Sergio A., López, Silvia, Martínez-Viturro, Carlos M., Tong, Han Min, Lavreysen, Hilde, Macdonald, Gregor J., Steckler, Thomas, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Noetzel, Meredith J., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Publicado no Bioorg Med Chem Lett (2015)

Discovery of VU0409551/JNJ-46778212: An mGlu(5) Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

Por Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott, Megens, Anton, Langlois, Xavier, Drinkenburg, Wilhelmus H., Ahnaou, Abdellah, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Publicado no ACS Med Chem Lett (2015)

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators

Por Malosh, Chrysa, Turlington, Mark, Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Piedrafita, María, Sánchez-Casado, M. Rosa, Macdonald, Gregor J., Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Publicado no Bioorg Med Chem Lett (2015)

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu(5) receptor positive allosteric modulators with efficacy in preclinical m...

Por Conde-Ceide, Susana, Alcázar, Jesús, Alonso de Diego, Sergio A., López, Silvia, Martín-Martín, María Luz, Martínez-Viturro, Carlos M., Pena, Miguel-Angel, Tong, Han Min, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Lindsley, Craig W., Bartolomé-Nebreda, José Manuel
Publicado no Bioorg Med Chem Lett (2015)