Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813

door Lavreysen, Hilde, Langlois, Xavier, Donck, Luc Ver, Nuñez, José María Cid, Pype, Stefan, Lütjens, Robert, Megens, Anton
Gepubliceerd in Pharmacol Res Perspect (2015)

PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways

door Megens, Anton A H P, Hendrickx, Herman M R, Mahieu, Michel M A, Wellens, Annemie L Y, de Boer, Peter, Vanhoof, Greet
Gepubliceerd in 2014

Discovery of VU0409551/JNJ-46778212: An mGlu(5) Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

door Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott, Megens, Anton, Langlois, Xavier, Drinkenburg, Wilhelmus H., Ahnaou, Abdellah, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Gepubliceerd in ACS Med Chem Lett (2015)