PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways

The enzyme phosphodiesterase 10A (PDE10A) regulates the activity of striatal, medium spiny neurons (MSNs), which are divided into a behaviorally stimulating, Gs-coupled D(1) receptor-expressing “direct” pathway and a behaviorally suppressant, Gi-coupled D(2) receptor-expressing “indirect” pathway. A...

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Detalhes bibliográficos
Principais autores: Megens, Anton A H P, Hendrickx, Herman M R, Mahieu, Michel M A, Wellens, Annemie L Y, de Boer, Peter, Vanhoof, Greet
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186443/
https://ncbi.nlm.nih.gov/pubmed/25505601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.57
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