Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813

JNJ-40411813/ADX71149 (1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl) pyridin-2(1H)-one) is a positive allosteric modulator (PAM) of the mGlu2 receptor, which also displays 5-Hydroxytryptamine (5HT(2A)) antagonism after administration in rodents due to a rodent-specific metabolite. JNJ-40411813 was com...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Lavreysen, Hilde, Langlois, Xavier, Donck, Luc Ver, Nuñez, José María Cid, Pype, Stefan, Lütjens, Robert, Megens, Anton
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324682/
https://ncbi.nlm.nih.gov/pubmed/25692027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.97
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