Discovery of VU0409551/JNJ-46778212: An mGlu(5) Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

[Image: see text] Herein, we report the structure–activity relationship of a novel series of (2(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridine-5(4H)-yl(aryl)methanones as potent, selective, and orally bioavailable metabotropic glutamate receptor subtype 5 (mGlu(5)) positive allosteric modulators (...

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Publicado no:ACS Med Chem Lett
Main Authors: Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott, Megens, Anton, Langlois, Xavier, Drinkenburg, Wilhelmus H., Ahnaou, Abdellah, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492464/
https://ncbi.nlm.nih.gov/pubmed/26157544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00181
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