Further optimization of the mGlu(5) PAM clinical candidate VU0409551/JNJ-46778212: progress and challenges towards a back-up compound

This letter describes the progress and challenges in the continued optimization of the mGlu(5) positive allosteric modulator (PAM) clinical candidate VU0490551/JNJ-46778212. While many analogs addressed key areas for improvement, no one compound possessed the amalgamation of improvements needed with...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Zhou, Ya, Malosh, Chrysa, Conde-Ceide, Susana, Martínez-Viturro, Carlos Manuel, Alcázar, Jesus, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535329/
https://ncbi.nlm.nih.gov/pubmed/26183084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.096
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