Editorial: preclinical data reproducibility for R&D - the challenge for neuroscience

door Steckler, Thomas
Gepubliceerd in Springerplus (2015)

Pharmacological Treatment of PTSD – Established and New Approaches

door Steckler, Thomas, Risbrough, Victoria
Gepubliceerd in 2011

Behavioral neurobiology of anxiety and its treatment

door Stein, Murray B., Steckler, Thomas.
Gepubliceerd in 2010

Stress-induced decreases in local cerebral glucose utilization in specific regions of the mouse brain

door Warnock, Geoff I, Steckler, Thomas
Gepubliceerd in 2011

Nicotine Improves Working Memory Span Capacity in Rats Following Sub-Chronic Ketamine Exposure

door Rushforth, Samantha L, Steckler, Thomas, Shoaib, Mohammed
Gepubliceerd in 2011

Removing obstacles in neuroscience drug discovery: The future path for animal models

door Markou, Athina, Chiamulera, Christian, Geyer, Mark A., Tricklebank, Mark, Steckler, Thomas
Gepubliceerd in 2008

Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator

door Pollard, Marie, Bartolome, Jose Manuel, Conn, P Jeffrey, Steckler, Thomas, Shaban, Hamdy
Gepubliceerd in J Psychopharmacol (2014)

Metabolomic biosignature differentiates melancholic depressive patients from healthy controls

door Liu, Yashu, Yieh, Lynn, Yang, Tao, Drinkenburg, Wilhelmus, Peeters, Pieter, Steckler, Thomas, Narayan, Vaibhav A., Wittenberg, Gayle, Ye, Jieping
Gepubliceerd in BMC Genomics (2016)

Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania

door Prickaerts, Jos, Moechars, Dieder, Cryns, Kim, Lenaerts, Ilse, van Craenendonck, Hansfried, Goris, Ilse, Daneels, Guy, Bouwknecht, J. Adriaan, Steckler, Thomas
Gepubliceerd in J Neurosci (2006)

Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain

door Vry, Jochen De, Martínez-Martínez, Pilar, Losen, Mario, Bode, Gerard H, Temel, Yasin, Steckler, Thomas, Steinbusch, Harry WM, Baets, Marc De, Prickaerts, Jos
Gepubliceerd in 2010

The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders

door Cocks, Graham, Curran, Sarah, Gami, Priya, Uwanogho, Dafe, Jeffries, Aaron R., Kathuria, Annie, Lucchesi, Walter, Wood, Victoria, Dixon, Rosemary, Ogilvie, Caroline, Steckler, Thomas, Price, Jack
Gepubliceerd in 2013

Discovery and SAR of a novel series of non-MPEP site mGlu(5) PAMs based on an aryl glycine sulfonamide scaffold

door Rodriguez, Alice L., Zhou, Ya, Williams, Richard, Weaver, C. David, Vinson, Paige N., Dawson, Eric S., Steckler, Thomas, Lavreysen, Hilde, Mackieg, Claire, Bartolomé, José M., Macdonald, Gregor J., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Gepubliceerd in 2012

Further optimization of the mGlu(5) PAM clinical candidate VU0409551/JNJ-46778212: progress and challenges towards a back-up compound

door Zhou, Ya, Malosh, Chrysa, Conde-Ceide, Susana, Martínez-Viturro, Carlos Manuel, Alcázar, Jesus, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Gepubliceerd in Bioorg Med Chem Lett (2015)

Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu(5): In Vitro to In Vivo Translation and Potential Impact on Clinic...

door Blobaum, Anna L., Bridges, Thomas M., Byers, Frank W., Turlington, Mark L., Mattmann, Margrith E., Morrison, Ryan D., Mackie, Claire, Lavreysen, Hilde, Bartolomé, José M., MacDonald, Gregor J., Steckler, Thomas, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R., Daniels, J. Scott
Gepubliceerd in 2013

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

door Turlington, Mark, Noetzel, Meredith J., Bridges, Thomas M., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Tong, Han Min, Macdonald, Gregor J., Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Gepubliceerd in Bioorg Med Chem Lett (2014)

Optimization of an ether series of mGlu(5) positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover

door Manka, Jason T., Vinson, Paige N., Gregory, Karen J., Zhou, Ya, Williams, Richard, Gogi, Kiran, Days, Emily, Jadhav, Satya, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M., Macdonald, Gregor J., Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Gepubliceerd in 2012

Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu(5))

door Martín-Martín, María Luz, Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Alonso de Diego, Sergio A., López, Silvia, Martínez-Viturro, Carlos M., Tong, Han Min, Lavreysen, Hilde, Macdonald, Gregor J., Steckler, Thomas, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Noetzel, Meredith J., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Gepubliceerd in Bioorg Med Chem Lett (2015)

Discovery of VU0409551/JNJ-46778212: An mGlu(5) Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

door Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott, Megens, Anton, Langlois, Xavier, Drinkenburg, Wilhelmus H., Ahnaou, Abdellah, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.
Gepubliceerd in ACS Med Chem Lett (2015)

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators

door Malosh, Chrysa, Turlington, Mark, Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Piedrafita, María, Sánchez-Casado, M. Rosa, Macdonald, Gregor J., Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Gepubliceerd in Bioorg Med Chem Lett (2015)

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu(5) receptor positive allosteric modulators with efficacy in preclinical m...

door Conde-Ceide, Susana, Alcázar, Jesús, Alonso de Diego, Sergio A., López, Silvia, Martín-Martín, María Luz, Martínez-Viturro, Carlos M., Pena, Miguel-Angel, Tong, Han Min, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Lindsley, Craig W., Bartolomé-Nebreda, José Manuel
Gepubliceerd in Bioorg Med Chem Lett (2015)