Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

We report the optimization of a series of novel metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs) from a 5,6-bicyclic class of dihydropyrazolo[1,5-a]pyridin-4(5H)-ones containing a phenoxymethyl linker. Studies focused on a survey of nonamide containing hydrogen bond...

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Publicado no:Bioorg Med Chem Lett
Main Authors: Turlington, Mark, Noetzel, Meredith J., Bridges, Thomas M., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Tong, Han Min, Macdonald, Gregor J., Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234308/
https://ncbi.nlm.nih.gov/pubmed/24961642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.04.087
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