Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu(5)) have emerged as an exciting new approach for the treatment of schizophrenia and other central nervous system (CNS) disorders. Of interest, some mGlu(5) PAMs act as pure PAMs, only potentiating mGlu(5) respon...

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Detalhes bibliográficos
Main Authors: Noetzel, Meredith J., Rook, Jerri M., Vinson, Paige N., Cho, Hyekyung P., Days, Emily, Zhou, Y., Rodriguez, Alice L., Lavreysen, Hilde, Stauffer, Shaun R., Niswender, Colleen M., Xiang, Zixiu, Daniels, J. Scott, Jones, Carrie K., Lindsley, Craig W., Weaver, C. David, Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263948/
https://ncbi.nlm.nih.gov/pubmed/22021324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.075184
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