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Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu(5)) have emerged as an exciting new approach for the treatment of schizophrenia and other central nervous system (CNS) disorders. Of interest, some mGlu(5) PAMs act as pure PAMs, only potentiating mGlu(5) respon...

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主要な著者: Noetzel, Meredith J., Rook, Jerri M., Vinson, Paige N., Cho, Hyekyung P., Days, Emily, Zhou, Y., Rodriguez, Alice L., Lavreysen, Hilde, Stauffer, Shaun R., Niswender, Colleen M., Xiang, Zixiu, Daniels, J. Scott, Jones, Carrie K., Lindsley, Craig W., Weaver, C. David, Conn, P. Jeffrey
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263948/
https://ncbi.nlm.nih.gov/pubmed/22021324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.075184
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