Emerging Approaches for Treatment of Schizophrenia: Modulation of Glutamatergic Signaling

od Noetzel, Meredith J., Jones, Carrie K., Conn, P. Jeffrey
Izdano 2012

Mechanisms of M3 Muscarinic Receptor Regulation by Wash-Resistant Xanomeline Binding

od Noetzel, Meredith J., Grant, Marianne K.O., El-Fakahany, Esam E.
Izdano 2009

Immediate and Delayed Consequences of Xanomeline Wash-Resistant Binding at the M3 Muscarinic Receptor

od Noetzel, Meredith J., Grant, Marianne K. O., El-Fakahany, Esam E.
Izdano 2008

Pharmacological Evaluation of the Long-Term Effects of Xanomeline on the M(1) Muscarinic Acetylcholine Receptor

od Grant, Marianne K. O., Noetzel, Meredith J., De Lorme, Kayla C., Jakubík, Jan, Doležal, Vladimír, El-Fakahany, Esam E.
Izdano 2010

Chemical Lead Optimization of a pan G(q) mAChR M(1), M(3), M(5) Positive Allosteric Modulator (PAM) Lead. Part II. Development of potent and highly selective M(1) PAM

od Bridges, Thomas M., Kennedy, J. Phillip, Noetzel, Meredith J., Breininger, Micah L., Gentry, Patrick R., Conn, P. Jeffrey, Lindsley, Craig W.
Izdano 2010

Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part I: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5...

od Han, Changho, Chatterjee, Arindam, Noetzel, Meredith J., Panarese, Joseph D., Niswender, Colleen, Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
izdano v Bioorg Med Chem Lett (2014)

Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

od Yin, Shen, Noetzel, Meredith J., Johnson, Kari A., Zamorano, Rocio, Jalan-Sakrikar, Nidhi, Gregory, Karen J., Conn, P. Jeffrey, Niswender, Colleen M.
Izdano 2014

In Vitro to in Vivo Translation of Allosteric Modulator Concentration-Effect Relationships: Implications for Drug Discovery

od Gregory, Karen J., Bridges, Thomas M., Gogliotti, Rocco G., Stauffer, Shaun R., Noetzel, Meredith J., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M.
izdano v ACS Pharmacol Transl Sci (2019)

Development of a Highly Potent, Novel M(5) Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piper...

od Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Izdano 2014

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M(4))

od Smith, Emery, Chase, Peter, Niswender, Colleen M., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Lamsal, Atin, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W., Madoux, Franck, Acosta, Mary, Scampavia, Louis, Spicer, Timothy, Hodder, Peter
izdano v J Biomol Screen (2015)

Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships

od Gregory, Karen J., Noetzel, Meredith J., Rook, Jerri M., Vinson, Paige N., Stauffer, Shaun R., Rodriguez, Alice L., Emmitte, Kyle A., Zhou, Ya, Chun, Aspen C., Felts, Andrew S., Chauder, Brian A., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey
Izdano 2012

Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agon...

od Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Morrison, Ryan D., Zhou, Ya, Gogliotti, Rocco D., Vinson, Paige N., Xiang, Zixiu, Jones, Carrie K., Niswender, Colleen M., Lindsley, Craig W., Stauffer, Shaun R., Conn, P. Jeffrey, Daniels, J. Scott
Izdano 2013

Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012

od Melancon, Bruce J., Lamers, Alexander P., Bridges, Thomas M., Sulikowski, Gary A., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Morrison, Ryan D., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Izdano 2011

Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site

od Gregory, Karen J., Nguyen, Elizabeth D., Malosh, Chrysa, Mendenhall, Jeffrey L., Zic, Jessica Z., Bates, Brittney S., Noetzel, Meredith J., Squire, Emma F., Turner, Eric M., Rook, Jerri M., Emmitte, Kyle A., Stauffer, Shaun R., Lindsley, Craig W., Meiler, Jens, Conn, P. Jeffrey
Izdano 2014

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Funct...

od Noetzel, Meredith J., Rook, Jerri M., Vinson, Paige N., Cho, Hyekyung P., Days, Emily, Zhou, Y., Rodriguez, Alice L., Lavreysen, Hilde, Stauffer, Shaun R., Niswender, Colleen M., Xiang, Zixiu, Daniels, J. Scott, Jones, Carrie K., Lindsley, Craig W., Weaver, C. David, Conn, P. Jeffrey
Izdano 2012

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

od Turlington, Mark, Noetzel, Meredith J., Bridges, Thomas M., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Tong, Han Min, Macdonald, Gregor J., Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
izdano v Bioorg Med Chem Lett (2014)

State-Dependent Alterations in Sleep/wake Architecture Elicited by the M(4) PAM VU0467154- Relation to Antipsychotic-like Drug Effects

od Gould, Robert W., Nedelcovych, Michael T., Gong, Xuewen, Tsai, Erica, Bubser, Michael, Bridges, Thomas M., Wood, Michael R., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Wood, Michael W., Ivarsson, Magnus, Noetzel, Meredith J., Daniels, J. Scott, Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
izdano v Neuropharmacology (2015)

Discovery and SAR of a novel series of potent, CNS penetrant M(4) PAMs based on a non-enolizable ketone core: Challenges in disposition

od Wood, Michael R., Noetzel, Meredith J., Tarr, James C., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Foster, Jarrett J., Smith, Emery, Chase, Peter, Hodder, Peter S., Engers, Darren W., Niswender, Colleen M., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
izdano v Bioorg Med Chem Lett (2016)

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

od Rook, Jerri M., Noetzel, Meredith J., Pouliot, Wendy A., Bridges, Thomas M., Vinson, Paige N., Cho, Hyekyung P., Zhou, Y., Gogliotti, Rocco D., Manka, Jason T., Gregory, Karen J., Stauffer, Shaun R., Dudek, F. Edward, Xiang, Z., Niswender, Colleen M., Daniels, J. Scott, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey
Izdano 2012

Exploration of Allosteric Agonism Structure-Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu(5)) Positive Allosteric Modulators (PAMs):...

od Turlington, Mark, Noetzel, Meredith J., Chun, Aspen, Zhou, Ya, Gogliotti, Rocco D., Nguyen, Elizabeth D., Gregory, Karen J., Vinson, Paige N., Rook, Jerri M., Gogi, Kiran K., Xiang, Zixiu, Bridges, Thomas M., Daniels, J. Scott, Jones, Carrie, Niswender, Colleen M., Meiler, Jens, Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.
Izdano 2013