Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

Por Fan, Jianjia, Zareyan, Shahab, Zhao, Wenchen, Shimizu, Yoko, Pfeifer, Tom A., Tak, Jun-Hyung, Isman, Murray B., Van den Hoven, Bernard, Duggan, Mark E., Wood, Michael W., Wellington, Cheryl L., Kulic, Iva
Publicado no PLoS One (2016)

Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

Por Sivakumaran, Sudhir, Cardarelli, Ross A., Maguire, Jamie, Kelley, Matt R., Silayeva, Liliya, Morrow, Danielle H., Mukherjee, Jayanta, Moore, Yvonne E., Mather, Robert J., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Zicha, Stephen, Moss, Stephen J., Deeb, Tarek Z.
Publicado no J Neurosci (2015)

State-Dependent Alterations in Sleep/wake Architecture Elicited by the M(4) PAM VU0467154- Relation to Antipsychotic-like Drug Effects

Por Gould, Robert W., Nedelcovych, Michael T., Gong, Xuewen, Tsai, Erica, Bubser, Michael, Bridges, Thomas M., Wood, Michael R., Duggan, Mark E., Brandon, Nicholas J., Dunlop, John, Wood, Michael W., Ivarsson, Magnus, Noetzel, Meredith J., Daniels, J. Scott, Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Publicado no Neuropharmacology (2015)

Discovery and SAR of a novel series of potent, CNS penetrant M(4) PAMs based on a non-enolizable ketone core: Challenges in disposition

Por Wood, Michael R., Noetzel, Meredith J., Tarr, James C., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Foster, Jarrett J., Smith, Emery, Chase, Peter, Hodder, Peter S., Engers, Darren W., Niswender, Colleen M., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

Por Schmidt, Azriel, Harada, Shun-Ichi, Kimmel, Donald B., Bai, Chang, Chen, Fang, Rutledge, Su Jane, Vogel, Robert L., Scafonas, Angela, Gentile, Michael A., Nantermet, Pascale V., McElwee-Witmer, Sheila, Pennypacker, Brenda, Masarachia, Patricia, Sahoo, Soumya P., Kim, Yuntae, Meissner, Robert S., Hartman, George D., Duggan, Mark E., Rodan, Gideon A., Towler, Dwight A., Ray, William J.
Publicado em 2009

Selective Activation of M(4) Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

Por Bubser, Michael, Bridges, Thomas M., Dencker, Ditte, Gould, Robert W., Grannan, Michael, Noetzel, Meredith J., Lamsal, Atin, Niswender, Colleen M., Daniels, J. Scott, Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Byers, Frank W., Wess, Jürgen, Duggan, Mark E., Dunlop, John, Wood, Michael W., Brandon, Nicholas J., Wood, Michael R., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Publicado no ACS Chem Neurosci (2014)

Challenges in the development of an M(4) PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Por Wood, Michael R., Noetzel, Meredith J., Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B., Weiner, Rebecca L., Cho, Hyekyung P., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Discovery of VU0467485/AZ13713945: An M(4) PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

Por Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Poslusney, Michael S., Nance, Kellie D., Hurtado, Miguel A., Luscombe, Vincent B., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Bubser, Michael, Blobaum, Anna L., Engers, Darren W., Niswender, Colleen M., Jones, Carrie K., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Publicado no ACS Med Chem Lett (2016)

Discovery and optimization of a novel series of highly CNS penetrant M(4) PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d] pyrimidine core

Por Wood, Michael R., Noetzel, Meredith J., Engers, Julie L., Bollinger, Katrina A., Melancon, Bruce J., Tarr, James C., Han, Changho, West, Mary, Gregro, Alison R., Lamsal, Atin, Chang, Sichen, Ajmera, Sonia, Smith, Emery, Chase, Peter, Hodder, Peter S., Bubser, Michael, Jones, Carrie K., Hopkins, Corey R., Emmitte, Kyle A., Niswender, Colleen M., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Publicado no Bioorg Med Chem Lett (2016)

Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Ver...

Por Schmidt, Azriel, Kimmel, Donald B., Bai, Chang, Scafonas, Angela, Rutledge, SuJane, Vogel, Robert L., McElwee-Witmer, Sheila, Chen, Fang, Nantermet, Pascale V., Kasparcova, Viera, Leu, Chih-tai, Zhang, Hai-Zhuan, Duggan, Mark E., Gentile, Michael A., Hodor, Paul, Pennypacker, Brenda, Masarachia, Patricia, Opas, Evan E., Adamski, Sharon A., Cusick, Tara E., Wang, Jiabing, Mitchell, Helen J., Kim, Yuntae, Prueksaritanont, Thomayant, Perkins, James J., Meissner, Robert S., Hartman, George D., Freedman, Leonard P., Harada, Shun-ichi, Ray, William J.
Publicado em 2010