"Molecular Switches" on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

Autor Wood, Michael R., Hopkins, Corey R., Brogan, John T., Conn, P. Jeffrey, Lindsley, Craig W.
Vydáno 2011

Allosteric modulation of the M(1) muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer′s disease

Autor Melancon, Bruce J., Tarr, James C., Panarese, Joseph D., Wood, Michael R., Lindsley, Craig W.
Vydáno 2013

THE ANTIPSYCHOTIC POTENTIAL OF MUSCARINIC ALLOSTERIC MODULATION

Autor Bridges, Thomas M., LeBois, Evan P., Hopkins, Corey R., Wood, Michael R., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W.
Vydáno v Drug News Perspect (2010)

Allosteric Modulation of 7 Transmembrane Spanning Receptors: Theory, Practice and Opportunities for CNS Drug Discovery()

Autor Melancon, Bruce J., Hopkins, Corey R., Wood, Michael R., Emmitte, Kyle A., Niswender, Colleen M., Christopoulos, Arthur, Conn, P. Jeffrey, Lindsley, Craig W.
Vydáno 2012

M(5) Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location

Autor Foster, Daniel J., Gentry, Patrick R., Lizardi-Ortiz, Jose E., Bridges, Thomas M., Wood, Michael R., Niswender, Colleen M., Sulzer, David, Lindsley, Craig W., Xiang, Zixiu, Conn, P. Jeffrey
Vydáno 2014

Chemical Modification of the M(1) Agonist VU0364572 Reveals Molecular Switches in Pharmacology and a Bitopic Binding Mode

Autor Digby, Gregory J., Utley, Thomas J., Lamsal, Atin, Sevel, Christian, Sheffler, Douglas J., Lebois, Evan P., Bridges, Thomas M., Wood, Michael R., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Vydáno 2012

Further optimization of the M(5) NAM MLPCN probe ML375: Tactics and challenges

Autor Kurata, Haruto, Gentry, Patrick R., Kokubo, Masaya, Cho, Hyekyung P., Bridges, Thomas M., Niswender, Colleen M., Byers, Frank W., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Vydáno v Bioorg Med Chem Lett (2014)

Spirocyclic replacements for the isatin in the highly selective, muscarinic M(1) PAM ML137: the continued optimization of an MLPCN probe molecule

Autor Poslusney, Michael S., Melancon, Bruce J., Gentry, Patrick R., Sheffler, Douglas J., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Vydáno 2013

Synthesis and biological characterization of a series of novel diaryl amide M(1) antagonists

Autor Poslusney, Michael S., Sevel, Christian, Utley, Thomas J., Bridges, Thomas M., Morrison, Ryan D., Kett, Nathan R., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. S., Conn, P. J., Lindsley, Craig W., Wood, Michael R.
Vydáno 2012

Discovery of ML326: the first sub-micromolar, selective M(5) PAM

Autor Gentry, Patirck R., Bridges, Thomas M., Lamasal, Atin, Vinson, Paige N., Smith, Emery, Chase, Peter, Hodder, Peter S., Engers, Julie L., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.
Vydáno 2013

Novel M(4) positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

Autor Poslusney, Michael S., Salovich, James M., Wood, Michael R., Melancon, Bruce J., Bollinger, Katrina A., Luscombe, Vincent B., Rodriguez, Alice L., Engers, Darren W., Bridges, Thomas M., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Vydáno v Bioorg Med Chem Lett (2018)

Further exploration of M(1) allosteric agonists: Subtle structural changes abolish M(1) allosteric agonism and result in pan-mAChR orthosteric antagonism

Autor Sheffler, Douglas J., Sevel, Christian, Le, Uyen, Lovell, Kimberly M., Tarr, James C., Carrington, Sheridan J. S., Cho, Hyekyung P., Digby, Gregory J., Niswender, Colleen M., Conn, P. Jeffrey, Hopkins, Corey R., Wood, Michael R., Lindsley, Craig W.
Vydáno 2012

Development of a Highly Potent, Novel M(5) Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piper...

Autor Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Vydáno 2014

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M(4))

Autor Smith, Emery, Chase, Peter, Niswender, Colleen M., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Lamsal, Atin, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W., Madoux, Franck, Acosta, Mary, Scampavia, Louis, Spicer, Timothy, Hodder, Peter
Vydáno v J Biomol Screen (2015)

Discovery and optimization of a novel, selective and brain penetrant M(1) positive allosteric modulator (PAM): the development of ML169, an MLPCN Probe

Autor Reid, Paul R., Bridges, Thomas M., Sheffler, Douglas J., Cho, Hyekyung P., Lewis, L. Michelle, Days, Emily, Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Vydáno 2010

Isatin replacements applied to the highly selective, muscarinic M(1) PAM ML137: Continued optimization of an MLPCN probe molecule

Autor Melancon, Bruce J., Poslusney, Michael S., Gentry, Patrick R., Tarr, James C., Sheffler, Douglas J., Mattmann, Margrith E., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Vydáno 2012

Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012

Autor Melancon, Bruce J., Utley, Thomas J., Sevel, Christian, Mattmann, Margrith E., Cheung, Yiu-Yin, Bridges, Thomas M., Morrison, Ryan D., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Vydáno 2012

Discovery of the first M(5)-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-...

Autor Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Kett, Nathan R., Harp, Joel M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.
Vydáno 2013

Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Autor Wen, Wandong, Young, Summer E., Duvernay, Matthew T., Schulte, Michael L., Nance, Kellie D., Melancon, Bruce J., Engers, Julie, Locuson, Charles W., Wood, Michael R., Daniels, J. Scott, Wu, Wenjun, Lindsley, Craig W., Hamm, Heidi E., Stauffer, Shaun R.
Vydáno v Bioorg Med Chem Lett (2014)

Development of a Highly Selective, Orally Bioavailable and CNS Penetrant M(1) Agonist Derived from the MLPCN Probe ML071

Autor Lebois, Evan P., Digby, Gregory J., Sheffler, Douglas J., Melancon, Bruce J., Tarr, James C., Cho, Hyekyung P., Miller, Nicoel R., Morrison, Ryan, Bridges, Thomas M., Xiang, Zixiu, Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.
Vydáno 2011