Further optimization of the M(5) NAM MLPCN probe ML375: Tactics and challenges

This letter describes the continued optimization of the MLPCN probe ML375, a highly selective M(5) negative allosteric modulator (NAM), through a combination of matrix libraries and iterative parallel synthesis. True to certain allosteric ligands, SAR was shallow, and the matrix library approach hig...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Kurata, Haruto, Gentry, Patrick R., Kokubo, Masaya, Cho, Hyekyung P., Bridges, Thomas M., Niswender, Colleen M., Byers, Frank W., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535335/
https://ncbi.nlm.nih.gov/pubmed/25542588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.082
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