Further optimization of the M(5) NAM MLPCN probe ML375: Tactics and challenges

Ítems similars

• Discovery of the first M(5)-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
  per: Gentry, Patrick R., et al.
  Publicat: (2013)
• Spirocyclic replacements for the isatin in the highly selective, muscarinic M(1) PAM ML137: the continued optimization of an MLPCN probe molecule
  per: Poslusney, Michael S., et al.
  Publicat: (2013)
• Isatin replacements applied to the highly selective, muscarinic M(1) PAM ML137: Continued optimization of an MLPCN probe molecule
  per: Melancon, Bruce J., et al.
  Publicat: (2012)
• Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012
  per: Melancon, Bruce J., et al.
  Publicat: (2012)
• Discovery and optimization of a novel, selective and brain penetrant M(1) positive allosteric modulator (PAM): the development of ML169, an MLPCN Probe
  per: Reid, Paul R., et al.
  Publicat: (2010)