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Isatin replacements applied to the highly selective, muscarinic M(1) PAM ML137: Continued optimization of an MLPCN probe molecule

This Letter describes the continued optimization of an MLPCN probe molecule (ML137) with a focused effort on the replacement/modification of the isatin moiety present in this highly selective M(1) PAM. A diverse range of structures were validated as viable replacements for the isatin, many of which...

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Detaylı Bibliyografya
Asıl Yazarlar: Melancon, Bruce J., Poslusney, Michael S., Gentry, Patrick R., Tarr, James C., Sheffler, Douglas J., Mattmann, Margrith E., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534865/
https://ncbi.nlm.nih.gov/pubmed/23237839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.11.092
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