Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM(1) muscarinic acetylcholine receptor

This Letter describes the continued optimization of the MLPCN probe molecule ML071. After introducing numerous cyclic constraints and novel substitutions throughout the parent structure, we produced a number of more highly potent agonists of the M(1) mACh receptor. While many novel agonists demonstr...

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Detalhes bibliográficos
Main Authors: Melancon, Bruce J., Gogliotti, Rocco D., Tarr, James C., Saleh, Sam A., Chauder, Brian A., Lebois, Evan P., Cho, Hyekyung P., Utley, Thomas J., Sheffler, Douglas J., Bridges, Thomas M., Morrison, Ryan D., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348459/
https://ncbi.nlm.nih.gov/pubmed/22507963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.03.088
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