Respiratory Syncytial Virus Induces Host RNA Stress Granules To Facilitate Viral Replication

Por Lindquist, Michael E., Lifland, Aaron W., Utley, Thomas J., Santangelo, Philip J., Crowe, James E.
Publicado em 2010

Reversion of Somatic Mutations of the Respiratory Syncytial Virus-Specific Human Monoclonal Antibody Fab19 Reveal a Direct Relationship Between Association Rate and Neutralizing Po...

Por Bates, John T., Keefer, Christopher J., Utley, Thomas J., Correia, Bruno E., Schief, William R., Crowe, James E.
Publicado em 2013

Respiratory Syncytial Virus Assembles into Structured Filamentous Virion Particles Independently of Host Cytoskeleton and Related Proteins

Por Shaikh, Fyza Y., Utley, Thomas J., Craven, Ryan E., Rogers, Meredith C., Lapierre, Lynne A., Goldenring, James R., Crowe, James E.
Publicado em 2012

Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation

Por Derdowski, Aaron, Peters, Timothy R., Glover, Nancy, Qian, Ray, Utley, Thomas J., Burnett, Atuhani, Williams, John V., Spearman, Paul, Crowe, James E.
Publicado em 2008

Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2

Por Utley, Thomas J., Ducharme, Nicole A., Varthakavi, Vasundhara, Shepherd, Bryan E., Santangelo, Philip J., Lindquist, Michael E., Goldenring, James R., Crowe, James E.
Publicado em 2008

Venezuelan Equine Encephalitis Virus Replicon Particles Encoding Respiratory Syncytial Virus Surface Glycoproteins Induce Protective Mucosal Responses in Mice and Cotton Rats

Por Mok, Hoyin, Lee, Sujin, Utley, Thomas J., Shepherd, Bryan E., Polosukhin, Vasiliy V., Collier, Martha L., Davis, Nancy L., Johnston, Robert E., Crowe, James E.
Publicado em 2007

Chemical Modification of the M(1) Agonist VU0364572 Reveals Molecular Switches in Pharmacology and a Bitopic Binding Mode

Por Digby, Gregory J., Utley, Thomas J., Lamsal, Atin, Sevel, Christian, Sheffler, Douglas J., Lebois, Evan P., Bridges, Thomas M., Wood, Michael R., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Publicado em 2012

Spirocyclic replacements for the isatin in the highly selective, muscarinic M(1) PAM ML137: the continued optimization of an MLPCN probe molecule

Por Poslusney, Michael S., Melancon, Bruce J., Gentry, Patrick R., Sheffler, Douglas J., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado em 2013

Synthesis and biological characterization of a series of novel diaryl amide M(1) antagonists

Por Poslusney, Michael S., Sevel, Christian, Utley, Thomas J., Bridges, Thomas M., Morrison, Ryan D., Kett, Nathan R., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. S., Conn, P. J., Lindsley, Craig W., Wood, Michael R.
Publicado em 2012

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M(4))

Por Smith, Emery, Chase, Peter, Niswender, Colleen M., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Lamsal, Atin, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W., Madoux, Franck, Acosta, Mary, Scampavia, Louis, Spicer, Timothy, Hodder, Peter
Publicado no J Biomol Screen (2015)

Isatin replacements applied to the highly selective, muscarinic M(1) PAM ML137: Continued optimization of an MLPCN probe molecule

Por Melancon, Bruce J., Poslusney, Michael S., Gentry, Patrick R., Tarr, James C., Sheffler, Douglas J., Mattmann, Margrith E., Bridges, Thomas M., Utley, Thomas J., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado em 2012

Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012

Por Melancon, Bruce J., Utley, Thomas J., Sevel, Christian, Mattmann, Margrith E., Cheung, Yiu-Yin, Bridges, Thomas M., Morrison, Ryan D., Sheffler, Douglas J., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado em 2012

Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012

Por Melancon, Bruce J., Lamers, Alexander P., Bridges, Thomas M., Sulikowski, Gary A., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Morrison, Ryan D., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado em 2011

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M(4)) re...

Por Salovich, James M., Vinson, Paige N., Sheffler, Douglas J., Lamsal, Atin, Utley, Thomas J., Blobaum, Anna L., Bridges, Thomas M., Le, Uyen, Jones, Carrie K., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Publicado em 2012

Discovery, synthesis and characterization of a highly mAChR selective M(5) orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

Por Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Utley, Thomas J., Rajapakse, Anuruddha, Byers, Frank, Niswender, Colleen M., Morrison, Ryan D., Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado em 2014

Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM(1) muscarinic acetylcholine receptor

Por Melancon, Bruce J., Gogliotti, Rocco D., Tarr, James C., Saleh, Sam A., Chauder, Brian A., Lebois, Evan P., Cho, Hyekyung P., Utley, Thomas J., Sheffler, Douglas J., Bridges, Thomas M., Morrison, Ryan D., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado em 2012

Discovery of a selective M(4) positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant co...

Por Le, Uyen, Melancon, Bruce J., Bridges, Thomas M., Vinson, Paige N., Utley, Thomas J., Lamsal, Atin, Rodriguez, Alice L., Venable, Daryl, Sheffler, Douglas J., Jones, Carrie K., Blobaum, Anna L., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Publicado em 2012

Targeting Selective Activation of M(1) for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M(1) Positive Allosteric...

Por Tarr, James C., Turlington, Mark L., Reid, Paul R., Utley, Thomas J., Sheffler, Douglas J., Cho, Hyekyung P., Klar, Rebecca, Pancani, Tristano, Klein, Michael T., Bridges, Thomas M., Morrison, Ryan D., Blobaum, Anna L., Xiang, Zixui, Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.
Publicado em 2012

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Por Jalan-Sakrikar, Nidhi, Field, Julie R., Klar, Rebecca, Mattmann, Margrith E., Gregory, Karen J., Zamorano, Rocio, Engers, Darren W., Bollinger, Sean R., Weaver, C. David, Days, Emily L., Lewis, L. Michelle, Utley, Thomas J., Hurtado, Miguel, Rigault, Delphine, Acher, Francine, Walker, Adam G., Melancon, Bruce J., Wood, Michael R., Lindsley, Craig W., Conn, P. Jeffrey, Xiang, Zixiu, Hopkins, Corey R., Niswender, Colleen M.
Publicado no ACS Chem Neurosci (2014)

Novel Allosteric Agonists of M(1) Muscarinic Acetylcholine Receptors Induce Brain Region-Specific Responses That Correspond with Behavioral Effects in Animal Models

Por Digby, Gregory J., Noetzel, Meredith J., Bubser, Michael, Utley, Thomas J., Walker, Adam G., Byun, Nellie E., Lebois, Evan P., Xiang, Zixiu, Sheffler, Douglas J., Cho, Hyekyung P., Davis, Albert A., Nemirovsky, Natali E., Mennenga, Sarah E., Camp, Bryan W., Bimonte-Nelson, Heather A., Bode, Jacob, Italiano, Kimberly, Morrison, Ryan, Daniels, J. Scott, Niswender, Colleen M., Olive, M. Foster, Lindsley, Craig W., Jones, Carrie K., Conn, P. Jeffrey
Publicado em 2012