Discovery, synthesis and characterization of a highly mAChR selective M(5) orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

Of the five G-protein-coupled muscarinic acetylcholine receptors (mAChRs or M(1)-M(5)), M(5) is the least explored and understood due to a lack of mAChR subtype selective ligands. We recently performed a high-throughput functional screen and identified a number of weak antagonist hits that were sele...

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Bibliografiske detaljer
Main Authors: Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Utley, Thomas J., Rajapakse, Anuruddha, Byers, Frank, Niswender, Colleen M., Morrison, Ryan D., Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116439/
https://ncbi.nlm.nih.gov/pubmed/24692176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402051
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