Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) anatgonists

This Letter describes the synthesis and SAR, developed through an iterative analog library approach, of a novel series of selective M1 mAChR antagonist for the potential treatment of Parkinson’s disease, dystonia and other movement disorders. Compounds in this series possess M1 antagonist IC(50)s in...

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Main Authors: Lewis, L. Michelle, Sheffler, Douglas, Williams, Richard, Bridges, Thomas M., Kennedy, J. Phillip, Brogan, J.T., Mulder, Matthew J., Williams, Lyndsey, Nalywajko, Natalia T., Niswender, Colleen M., Weaver, Charles D., Conn, P. Jeffrey, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275053/
https://ncbi.nlm.nih.gov/pubmed/18178088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.12.051
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