Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M(1)) antagonist in vitro and in vivo probe

This article describes the discovery and development of the first highly selective, small molecule antagonist of the muscarinic acetylcholine receptor subtype I (mAChR1 or M(1)). An M(1) functional, cell-based calcium-mobilization assay identified three distinct chemical series with initial selectiv...

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Publicado no:Curr Top Med Chem
Main Authors: Weaver, C. David, Sheffler, Douglas J., Lewis, L. Michelle, Bridges, Thomas M., Williams, Richard, Nalywajko, Natalia T., Kennedy, J. Phillip, Mulder, Matthew M., Jadhav, Satyawan, Aldrich, Leslie A., Jones, Carrie K., Marlo, Joy, Niswender, Colleen M., Mock, Matthew M., Zheng, Fang, Conn, P. Jeffrey, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4765323/
https://ncbi.nlm.nih.gov/pubmed/19807667
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