Discovery, synthesis and characterization of a highly mAChR selective M(5) orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

Of the five G-protein-coupled muscarinic acetylcholine receptors (mAChRs or M(1)-M(5)), M(5) is the least explored and understood due to a lack of mAChR subtype selective ligands. We recently performed a high-throughput functional screen and identified a number of weak antagonist hits that were sele...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Utley, Thomas J., Rajapakse, Anuruddha, Byers, Frank, Niswender, Colleen M., Morrison, Ryan D., Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116439/
https://ncbi.nlm.nih.gov/pubmed/24692176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402051
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados