Discovery, synthesis and characterization of a highly mAChR selective M(5) orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

Of the five G-protein-coupled muscarinic acetylcholine receptors (mAChRs or M(1)-M(5)), M(5) is the least explored and understood due to a lack of mAChR subtype selective ligands. We recently performed a high-throughput functional screen and identified a number of weak antagonist hits that were sele...

詳細記述

保存先:
書誌詳細
主要な著者: Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Cho, Hyekyung P., Smith, Emery, Chase, Peter, Hodder, Peter S., Utley, Thomas J., Rajapakse, Anuruddha, Byers, Frank, Niswender, Colleen M., Morrison, Ryan D., Daniels, J. Scott, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116439/
https://ncbi.nlm.nih.gov/pubmed/24692176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402051
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料