Chemical Modification of the M(1) Agonist VU0364572 Reveals Molecular Switches in Pharmacology and a Bitopic Binding Mode

od Digby, Gregory J., Utley, Thomas J., Lamsal, Atin, Sevel, Christian, Sheffler, Douglas J., Lebois, Evan P., Bridges, Thomas M., Wood, Michael R., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Wydane 2012

Development of a Highly Potent, Novel M(5) Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piper...

od Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Wydane 2014

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M(4))

od Smith, Emery, Chase, Peter, Niswender, Colleen M., Utley, Thomas J., Sheffler, Douglas J., Noetzel, Meredith J., Lamsal, Atin, Wood, Michael R., Conn, P. Jeffrey, Lindsley, Craig W., Madoux, Franck, Acosta, Mary, Scampavia, Louis, Spicer, Timothy, Hodder, Peter
Wydane w J Biomol Screen (2015)

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M(4)) re...

od Salovich, James M., Vinson, Paige N., Sheffler, Douglas J., Lamsal, Atin, Utley, Thomas J., Blobaum, Anna L., Bridges, Thomas M., Le, Uyen, Jones, Carrie K., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Wydane 2012

Discovery of a selective M(4) positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant co...

od Le, Uyen, Melancon, Bruce J., Bridges, Thomas M., Vinson, Paige N., Utley, Thomas J., Lamsal, Atin, Rodriguez, Alice L., Venable, Daryl, Sheffler, Douglas J., Jones, Carrie K., Blobaum, Anna L., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Wydane 2012

Discovery and SAR of a novel series of potent, CNS penetrant M(4) PAMs based on a non-enolizable ketone core: Challenges in disposition

od Wood, Michael R., Noetzel, Meredith J., Tarr, James C., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Foster, Jarrett J., Smith, Emery, Chase, Peter, Hodder, Peter S., Engers, Darren W., Niswender, Colleen M., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w Bioorg Med Chem Lett (2016)

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides

od Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Bertron, Jeanette, Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w Bioorg Med Chem Lett (2017)

Challenges in the development of an M(4) PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides

od Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Lamsal, Atin, Luscombe, Vincent B., Rodriguez, Alice L., Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Engers, Darren W., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w Bioorg Med Chem Lett (2017)

Corrigendum to “Challenges in the development of an M(4) PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary am...

od Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Lamsal, Atin, Luscombe, Vincent B., Rodriguez, Alice L., Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Engers, Darren W., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w Bioorg Med Chem Lett (2018)

Selective Activation of M(4) Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

od Bubser, Michael, Bridges, Thomas M., Dencker, Ditte, Gould, Robert W., Grannan, Michael, Noetzel, Meredith J., Lamsal, Atin, Niswender, Colleen M., Daniels, J. Scott, Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Byers, Frank W., Wess, Jürgen, Duggan, Mark E., Dunlop, John, Wood, Michael W., Brandon, Nicholas J., Wood, Michael R., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K.
Wydane w ACS Chem Neurosci (2014)

Challenges in the development of an M(4) PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

od Wood, Michael R., Noetzel, Meredith J., Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B., Weiner, Rebecca L., Cho, Hyekyung P., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w Bioorg Med Chem Lett (2016)

Optimization of M(4) positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

od Melancon, Bruce J., Wood, Michael R., Noetzel, Meredith J., Nance, Kellie D., Engelberg, Eileen M., Han, Changho, Lamsal, Atin, Chang, Sichen, Cho, Hyekyung P., Byers, Frank W., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Wu, Dedong, Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w Bioorg Med Chem Lett (2017)

Discovery of VU0467485/AZ13713945: An M(4) PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

od Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Poslusney, Michael S., Nance, Kellie D., Hurtado, Miguel A., Luscombe, Vincent B., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Bubser, Michael, Blobaum, Anna L., Engers, Darren W., Niswender, Colleen M., Jones, Carrie K., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w ACS Med Chem Lett (2016)

Discovery and optimization of a novel series of highly CNS penetrant M(4) PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d] pyrimidine core

od Wood, Michael R., Noetzel, Meredith J., Engers, Julie L., Bollinger, Katrina A., Melancon, Bruce J., Tarr, James C., Han, Changho, West, Mary, Gregro, Alison R., Lamsal, Atin, Chang, Sichen, Ajmera, Sonia, Smith, Emery, Chase, Peter, Hodder, Peter S., Bubser, Michael, Jones, Carrie K., Hopkins, Corey R., Emmitte, Kyle A., Niswender, Colleen M., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Wydane w Bioorg Med Chem Lett (2016)

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M(4) PAMs

od Chopko, Trevor C., Han, Changho, Gregro, Alison R., Engers, Darren W., Felts, Andrew S., Poslusney, Mike S., Bollinger, Katrina A., Morrison, Ryan D., Bubser, Michael, Lamsal, Atin, Luscombe, Vincent B., Cho, Hyekyung P., Schnetz-Boutaud, Nathalie C., Rodriguez, Alice L., Chang, Sichen, Daniels, J. Scott, Stec, Donald F., Niswender, Colleen M., Jones, Carrie K., Wood, Michael R., Wood, Michael W., Duggan, Mark E., Brandon, Nicholas J., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W., Melancon, Bruce J.
Wydane w Bioorg Med Chem Lett (2019)